منابع مشابه
Irisin and FNDC5 in retrospect
FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue where it induced a transition to brown fat. ...
متن کاملIrisin and FNDC5 in retrospect An exercise hormone or a transmembrane receptor?
FNDC5 (fibronectin domain-containing [protein] 5) was initially discovered and characterized by two groups in 2002. In 2011 FNDC5 burst into prominence as the parent of irisin, a small protein containing the fibronectin type III domain. Irisin was proposed to be secreted by skeletal muscle cells in response to exercise, and to circulate to fat tissue where it induced a transition to brown fat. ...
متن کاملIrisin/FNDC5--An updated review.
OBJECTIVE The irisin, recently identified novel molecule, has been shown to be secreted from fibronectin type III domain containing 5 (FNDC5) of skeletal muscle by an unknown protease. It has been proposed that this molecule plays an important role in converting the white adipose tissue to brown adipose tissue and regulating the energy expenditure. Apart from this, its expression and role in va...
متن کاملThe Diagnostic Value of FNDC5/Irisin in Renal Cell Cancer.
PURPOSES The aim of this study was to determine the diagnostic significance of fibronectin type III domain containing protein 5 (FNDC5)/Irisin levels in the sera of patients with renal cell cancer. MATERIALS AND METHODS In the study, 48 individuals were evaluated. The patient group included 23 subjects diagnosed with renal tumor, and the control group of 25 healthy individuals. Patients diagn...
متن کاملCan Resistance Exercise Alter Irisin Levels and Expression Profiles of FNDC5 and UCP1 in Rats?
BACKGROUND Irisin is a new myokine secreted from the skeletal muscle and appears to affect the metabolism of adipose tissue. OBJECTIVES The mechanisms of cellular and molecular identification by which exercise training exerts its benefits remain unclear and are under investigation. METHODS We examined the effect of 8-week resistance exercise on plasma irisin levels and expression profiles o...
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ژورنال
عنوان ژورنال: Adipocyte
سال: 2013
ISSN: 2162-3945,2162-397X
DOI: 10.4161/adip.26082